'A book that would have had Darwin swooning - anyone seriously interested in who we are and how we function should read this.'  Guardian At the beginning of this century enormous progress had been made in genetics. The Human Genome Project finished sequencing human DNA. It seemed it was only a matter of time until we had all the answers to the secrets of life on this planet.The cutting-edge of biology, however, is telling us that we still don't even know all of the questions.How is it that, despite each cell in your body carrying exactly the same DNA, you don't have teeth growing out of your eyeballs or toenails on your liver? How is it that identical twins share exactly the same DNA and yet can exhibit dramatic differences in the way that they live and grow?It turns out that cells read the genetic code in DNA more like a script to be interpreted than a mould that replicates the same result each time. This is epigenetics and it's the fastest-moving field in biology today.The Epigenetics Revolution traces the thrilling path this discipline has taken over the last twenty years. Biologist Nessa Carey deftly explains such diverse phenomena as how queen bees and ants control their colonies, why tortoiseshell cats are always female, why some plants need a period of cold before they can flower, why we age, develop disease and become addicted to drugs, and much more. Most excitingly, Carey reveals the amazing possibilities for humankind that epigenetics offers for us all - and in the surprisingly near future. Read more

“A fascinating exploration of the mysteries ignited by DNA genealogy testing—from the intensely personal and concrete to the existential and unsolvable.” —Tana French, New York Times–bestselling author You swab your cheek or spit in a vial, then send it away to a lab somewhere. Weeks later you get a report that might tell you where your ancestors came from or if you carry certain genetic risks. Or, the report could reveal a long-buried family secret that upends your entire sense of identity. Soon a lark becomes an obsession, a relentless drive to find answers to questions at the core of your being, like “Who am I?” and “Where did I come from?” Welcome to the age of home genetic testing.In The Lost Family, journalist Libby Copeland investigates what happens when we embark on a vast social experiment with little understanding of the ramifications. She explores the culture of genealogy buffs, the science of DNA, and the business of companies like Ancestry and 23andMe, all while tracing the story of one woman, her unusual results, and a relentless methodical drive for answers that becomes a thoroughly modern genetic detective story. Gripping and masterfully told, The Lost Family is a spectacular book on a big, timely subject.“An urgently necessary, powerful book that addresses one of the most complex social and bioethical issues of our time.” —Dani Shapiro, New York Times–bestselling author“Before you spit in that vial, read this book.” —The New York Times Book Review“Impeccably researched . . . up-to-the-minute science meets the philosophy of identity in a poignant, engaging debut.” —Kirkus Reviews (starred review) Read more

First there was the genetic revolution—the discovery that physical structures in the cell, including DNA and RNA, shape every organism. Now, says evolutionary biologist Richard Sternberg, we are overdue for another and more profound revolution. Recent findings reveal that genetic and even epigenetic sources alone cannot account for the rich dynamism of life—not even close. Some other informational source is required.The idea was anticipated 2,400 years ago in Plato’s Timaeus, and periodically revisited in the ensuing centuries. Sidelined by scientific materialism, it is now reasserting itself on the strength of cutting-edge molecular biology, higher mathematics, and commonsense reasoning. In Plato’s Revenge, science writer David Klinghoffer takes Sternberg’s profound explorations and weaves them into a lively and accessible account of a most remarkable realization: At every moment, we owe our lives to a genome that is more than matter, and to an informational source that is immaterial, transcomputational, and beyond space and time. Read more

A NEW YORK TIMES BESTSELLER “Brilliant and enthralling.”​ —The Wall Street Journal A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time’s most influential people.It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.” This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger. Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat—that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it. Read more

The million copy international bestseller, critically acclaimed and translated into over 25 languages.As influential today as when it was first published, The Selfish Gene has become a classic exposition of evolutionary thought. Professor Dawkins articulates a gene's eye view of evolution - a view giving centre stage to these persistent units of information, and in which organisms can be seen as vehicles for their replication. This imaginative, powerful, and stylistically brilliant work not only brought the insights of Neo-Darwinism to a wide audience, but galvanized the biologycommunity, generating much debate and stimulating whole new areas of research. Forty years later, its insights remain as relevant today as on the day it was published.This 40th anniversary edition includes a new epilogue from the author discussing the continuing relevance of these ideas in evolutionary biology today, as well as the original prefaces and foreword, and extracts from early reviews.Oxford Landmark Science books are 'must-read' classics of modern science writing which have crystallized big ideas, and shaped the way we think. Read more

From a renowned biologist and best-selling author, a whole new way of looking at living organisms: reading them as documents describing ancient worlds  “Richard Dawkins’s new book is a glorious affair. Profusely illustrated in color by Jana Lenzová, it is arguably his most joyous ode to the wonders that evolution has wrought in the animal world.”—Philip Ball, Science   An exquisitely camouflaged lizard has a desiccated landscape of sand and stones “painted” on its back. Its skin can be read as a description of an ancient desert, a world in which its ancestors survived. Such descriptions are more than skin deep, however. They penetrate the very warp and woof of the entire animal.   In this groundbreaking exploration of the power of Darwinian evolution and what it can reveal about the past, Richard Dawkins shows how the body, behavior, and genes of every living creature can be read as a book—an archive of the worlds of its ancestors. In the future, a zoologist presented with a hitherto unknown animal will be able to decode its ancestral history, to read its unique “book of the dead.” Such readings are already uncovering the remarkable ways animals overcome obstacles, adapt to their environments, and, again and again, develop remarkably similar ways of solving life’s problems.   From the author of The Selfish Gene comes a revolutionary, richly illustrated book that unlocks the door to a past more vivid, nuanced, and fascinating than anything we have seen. Read more

From New York Times bestselling author Sam Kean comes incredible stories of science, history, language, and music, as told by our own DNA. In The Disappearing Spoon, bestselling author Sam Kean unlocked the mysteries of the periodic table. In The Violinist's Thumb, he explores the wonders of the magical building block of life: DNA. There are genes to explain crazy cat ladies, why other people have no fingerprints, and why some people survive nuclear bombs. Genes illuminate everything from JFK's bronze skin (it wasn't a tan) to Einstein's genius. They prove that Neanderthals and humans bred thousands of years more recently than any of us would feel comfortable thinking. They can even allow some people, because of the exceptional flexibility of their thumbs and fingers, to become truly singular violinists. Kean's vibrant storytelling once again makes science entertaining, explaining human history and whimsy while showing how DNA will influence our species' future. Read more

"Valley of Forgetting reminds us that scientific progress is measured not only in breakthroughs but also through the sacrifices people make, the trust that is built. It is a tender story of the unshakable will to make meaning in the face of inexorable loss. . . . Smith elegantly captures what it means to love, to belong, to hold on to one another when so much is uncertain.” —Washington PostThe riveting account of a community from the remote mountains of Colombia whose rare and fatal genetic mutation is unlocking the secrets of Alzheimer’s diseaseIn the 1980s, a neurologist named Francisco Lopera traveled on horseback into the mountains seeking families with symptoms of dementia. For centuries, residents of certain villages near Medellín had suffered memory loss as they reached middle age, going on to die in their fifties. Lopera discovered that a unique genetic mutation was causing their rare hereditary form of early onset Alzheimer’s disease. Over the next forty years of working with the “paisa mutation” kindred, he went on to build a world-class research program in a region beset by violence and poverty.In Valley of Forgetting, Jennie Erin Smith brings readers into the clinic, the laboratories, and the Medellín trial center where Lopera’s patients receive an experimental drug to see if Alzheimer’s can be averted. She chronicles the lives of people who care for sick parents, spouses, and siblings, all while struggling to keep their own dreams afloat. These Colombian families have donated hundreds of their loved ones’ brains to science and subjected themselves to invasive testing to help uncover how Alzheimer’s develops and whether it can be stopped. Findings from this unprecedented effort could hold the key to understanding and treating the disease, though it is unclear what, if anything, the families will receive in return.Smith’s immersive storytelling brings this complex drama to life, inviting readers on a scientific journey that is as deeply moving as it is engrossing. Read more

A Best Book of 2021 by Bloomberg BusinessWeek, Time, and The Washington Post The bestselling author of Leonardo da Vinci and Steve Jobs returns with a “compelling” (The Washington Post) account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies.When Jennifer Doudna was in sixth grade, she came home one day to find that her dad had left a paperback titled The Double Helix on her bed. She put it aside, thinking it was one of those detective tales she loved. When she read it on a rainy Saturday, she discovered she was right, in a way. As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would. Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his codiscovery of the structure of DNA. She and her collaborators turned a curiosity of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020. Her story is an “enthralling detective story” (Oprah Daily) that involves the most profound wonders of nature, from the origins of life to the future of our species. Read more

National Book Critics Circle Award—2017 Nonfiction Finalist“Nothing less than a tour de force—a heady amalgam of science, history, a little bit of anthropology and plenty of nuanced, captivating storytelling.”—The New York Times Book Review, Editor’s ChoiceA National Geographic Best Book of 2017In our unique genomes, every one of us carries the story of our species—births, deaths, disease, war, famine, migration, and a lot of sex. But those stories have always been locked away—until now. Who are our ancestors? Where did they come from? Geneticists have suddenly become historians, and the hard evidence in our DNA has blown the lid off what we thought we knew. Acclaimed science writer Adam Rutherford explains exactly how genomics is completely rewriting the human story—from 100,000 years ago to the present. Read more

Why do human beings behave as they do? 'Awe-inspiring... You will learn more about human nature than in any other book I can think of' Henry Marsh, bestselling author of And Finally.We are capable of savage acts of violence but also spectacular feats of kindness: is one side of our nature destined to win out over the other?Every act of human behaviour has multiple layers of causation, spiralling back seconds, minutes, hours, days, months, years, even centuries, right back to the dawn of time and the origins of our species.In the epic sweep of history, how does our biology affect the arc of war and peace, justice and persecution? How have our brains evolved alongside our cultures?This is the exhilarating story of human morality and the science underpinning the biggest question of all: what makes us human?'One of the best scientist-writers of our time' Oliver Sacks Read more

2019 PEN/E.O. Wilson Literary Science Writing Award Finalist"Science book of the year"—The GuardianOne of New York Times 100 Notable Books for 2018One of Publishers Weekly's Top Ten Books of 2018One of Kirkus's Best Books of 2018 One of Mental Floss's Best Books of 2018One of Science Friday's Best Science Books of 2018“Extraordinary”—New York Times Book Review   "Magisterial"—The Atlantic"Engrossing"—Wired"Leading contender as the most outstanding nonfiction work of the year"—Minneapolis Star-TribuneCelebrated New York Times columnist and science writer Carl Zimmer presents a profoundly original perspective on what we pass along from generation to generation. Charles Darwin played a crucial part in turning heredity into a scientific question, and yet he failed spectacularly to answer it. The birth of genetics in the early 1900s seemed to do precisely that. Gradually, people translated their old notions about heredity into a language of genes. As the technology for studying genes became cheaper, millions of people ordered genetic tests to link themselves to missing parents, to distant ancestors, to ethnic identities...But, Zimmer writes, “Each of us carries an amalgam of fragments of DNA, stitched together from some of our many ancestors. Each piece has its own ancestry, traveling a different path back through human history. A particular fragment may sometimes be cause for worry, but most of our DNA influences who we are—our appearance, our height, our penchants—in inconceivably subtle ways.” Heredity isn’t just about genes that pass from parent to child. Heredity continues within our own bodies, as a single cell gives rise to trillions of cells that make up our bodies. We say we inherit genes from our ancestors—using a word that once referred to kingdoms and estates—but we inherit other things that matter as much or more to our lives, from microbes to technologies we use to make life more comfortable. We need a new definition of what heredity is and, through Carl Zimmer’s lucid exposition and storytelling, this resounding tour de force delivers it. Weaving historical and current scientific research, his own experience with his two daughters, and the kind of original reporting expected of one of the world’s best science journalists, Zimmer ultimately unpacks urgent bioethical quandaries arising from new biomedical technologies, but also long-standing presumptions about who we really are and what we can pass on to future generations. Read more

“This brilliant book is a virtual Voyage of the Beagle! Carl Zimmer shows, with the benefit of a hundred and fifty years of hindsight, how right Darwin was.” —Steve Jones, author of Darwin’s GhostDarwin’s The Origin of Species was breathtaking—beautifully written, staunchly defended, defiantly radical. Yet it emerged long before modern genetics, molecular biology, and contemporary findings in paleontology.In this remarkable book, a rich and up-to-date view of evolution is presented that explores the far-reaching implications of Darwin’s theory. At a time when controversies surrounding creationism and education are bursting into public consciousness, this book’s emphasis on the power, significance, and relevance of evolution will make it a catalyst for public debate. Evolution marks a turning point in the 150-year debate and will be an indispensable asset to any serious reader with an interest in the life sciences, a passion for truth in education, or a concern for the future of the planet.“The evolution of life over four billion years is a grand narrative, full of plots, intrigues, surprises and deaths. Carl Zimmer tells the tale with zest and style.” —Matt Ridley, New York Times–bestselling author “Proceeding from the flurry of preparations for Darwin’s famous voyage, Carl Zimmer leads us off on a journey of our own, tracking the development—and the implications—of one of the most powerful ideas in the biological sciences.” —Scientific American“Science writer Zimmer does a superb job of providing a sweeping overview of most of the topics critical to understanding evolution, presenting his material from both a historical and a topical perspective.” —Publishers Weekly“Popular science that will truly be popular.” —Booklist Read more

A pioneering scientist presents a mind-expanding account of the sociogenomics revolution, which promises to upend everything we know about human development.For more than 150 years, the question of nature versus nurture has been one of the most contentious issues in the human sciences. On the one side are “blank-slaters,” who believe we are mainly shaped by our environment. On the other side are “hereditarians,” who believe in the primacy of genes. From the start, the fight has been highly politicized and extremely bitter, given that it has implications for how we think about racial disparities, meritocracy, reproduction, and free will itself. In The Social Genome, pioneering scientist Dalton Conley demonstrates that this longstanding debate is fundamentally misguided. The true question is not nature versus nurture, but how nature and nurture interact to make each of us who we become.The Social Genome is a sweeping account of the sociogenomics revolution, which has, in the last decade, upended many of our notions about human development. Sociogenomics brings together advances in molecular genetics and traditional social and behavioral science. The key tool is the polygenic index, which allows us to analyze DNA to measure a child’s genetic potential. Today, we can estimate a child’s adult height, how far they will go in school, and their weight as an adult—all from a cheek swab, finger prick, or vial of saliva. Conley and other researchers are using this new science to shed light on the ways in which genes shape our world, influencing how each person both creates and responds to the environment around them. Conley reveals a world where children’s DNA influences the nurture they extract from their parents; the genes of our schoolmates affect our likelihood of smoking as much as our own DNA does; and spouses’ genes influence each other’s moods and behaviors. Looking forward, Conley envisions a future where dating, education, public health, and other institutions have been radically altered by the sociogenomic revolution.As Conley argues, we should no longer think of nature versus nurture, but about how our genes seek the nurture they need to express themselves and how, in turn, our environments are made partly from the genes of other people. The Social Genome presents a nuanced, powerful perspective on individual potential and social dynamics and raises critical ethical questions about how we will navigate a future where we have access to far more genetic information than ever before. Read more

AN INSTANT NEW YORK TIMES BESTSELLER!From celebrated anthropologist Jennifer Raff comes the untold story—and fascinating mystery—of how humans migrated to the Americas.ORIGIN is the story of who the first peoples in the Americas were, how and why they made the crossing, how they dispersed south, and how they lived based on a new and powerful kind of evidence: their complete genomes. ORIGIN provides an overview of these new histories throughout North and South America, and a glimpse into how the tools of genetics reveal details about human history and evolution.20,000 years ago, people crossed a great land bridge from Siberia into Western Alaska and then dispersed southward into what is now called the Americas. Until we venture out to other worlds, this remains the last time our species has populated an entirely new place, and this event has been a subject of deep fascination and controversy. No written records—and scant archaeological evidence—exist to tell us what happened or how it took place. Many different models have been proposed to explain how the Americas were peopled and what happened in the thousands of years that followed.  A study of both past and present, ORIGIN explores how genetics is currently being used to construct narratives that profoundly impact Indigenous peoples of the Americas. It serves as a primer for anyone interested in how genetics has become entangled with identity in the way that society addresses the question "Who is indigenous?" Read more

An easy-to-use, straightforward guide for British family historians looking to trace their ancestry using DNA testing.   DNA research is one of the most rapidly advancing areas in modern science, and the practical use of DNA testing in genealogy is one of its most exciting applications. Yet there is no recent British publication in this field. That is why this accessible, wide-ranging introduction is so valuable. It offers a clear, practical way into the subject, explaining the scientific discoveries and techniques and illustrating with case studies how it can be used by genealogists to gain an insight into their ancestry.   The subject is complex and perhaps difficult for traditional genealogists to understand but, with the aid of this book, novices who are keen to take advantage of it will be able to interpret test results and use them to help answer genealogical questions which cannot be answered by documentary evidence alone. It will also appeal to those with some experience in the field because it places the practical application of genetic genealogy within a wider context, highlighting its role as a genealogical tool and suggesting how it can be made more effective. Read more

A groundbreaking book about how ancient DNA has profoundly changed our understanding of human history. Geneticists like David Reich have made astounding advances in the field of genomics, which is proving to be as important as archeology, linguistics, and written records as a means to understand our ancestry.  In Who We Are and How We Got Here, Reich allows readers to discover how the human genome provides not only all the information a human embryo needs to develop but also the hidden story of our species. Reich delves into how the genomic revolution is transforming our understanding of modern humans and how DNA studies reveal deep inequalities among different populations, between the sexes, and among individuals. Provocatively, Reich’s book suggests that there might very well be biological differences among human populations but that these differences are unlikely to conform to common stereotypes. Drawing upon revolutionary findings and unparalleled scientific studies, Who We Are and How We Got Here is a captivating glimpse into humankind—where we came from and what that says about our lives today. Read more

A Harvard biologist and master inventor explores how new biotechnologies will enable us to bring species back from the dead, unlock vast supplies of renewable energy, and extend human life. In Regenesis, George Church and science writer Ed Regis explore the possibilities of the emerging field of synthetic biology. Synthetic biology, in which living organisms are selectively altered by modifying substantial portions of their genomes, allows for the creation of entirely new species of organisms. These technologies-far from the out-of-control nightmare depicted in science fiction-have the power to improve human and animal health, increase our intelligence, enhance our memory, and even extend our life span. A breathtaking look at the potential of this world-changing technology, Regenesis is nothing less than a guide to the future of life. Read more

A geneticist and internationally recognized anti-racism educator provides a powerful, science-based rebuttal to common fallacies about human difference.   Well-meaning physicians, parents, and even scientists today often spread misinformation about what biology can and can’t tell us about our bodies, minds, and identities. In this accessible, myth-busting book, geneticist Shoumita Dasgupta draws on the latest science to correct common misconceptions about how much of our social identities are actually based in genetics.   Dasgupta weaves together history, current affairs, and cutting-edge science to break down how genetic concepts are misused and how we can approach scientific evidence in a socially responsible way. With a unifying and intersectional approach disentangling biology from bigotry, the book moves beyond race and gender to incorporate categories like sexual orientation, disability, and class. Where Biology Ends and Bias Begins is an invaluable, empowering resource for biologists, geneticists, science educators, and anyone working against bias in their community. Read more

This authoritative debunking of racist claims that masquerade as “genetics” is a timely weapon against the misuse of science to justify bigotry—now in paperbackRace is not a biological reality.Racism thrives on our not knowing this.In fact, racist pseudoscience has become so commonplace that it can be hard to spot. But its toxic effects on society are plain to see: rising nationalism, simmering hatred, lost lives, and divisive discourse. Since cutting-edge genetics are difficult to grasp—and all too easy to distort—even well-intentioned people repeat stereotypes based on “science.” But the real science tells a different story: The more researchers learn about who we are and where we come from, the clearer it becomes that our racial divides have nothing to do with observable genetic differences. The bestselling author of A Brief History of Everyone Who Ever Lived explains in this explosive, essential guide to the DNA we all share. Read more