Thoroughly updated to reflect major advances in the field of immuno-oncology, this second edition of Cancer Immunotherapy Principles and Practice, from the Society for Immunotherapy of Cancer (SITC), remains the definitive resource for information on tumor immunology and cancer immunotherapy treatments. An essential reference for both novice and experienced cancer researchers, oncologists, and related practitioners alike, the book not only guides readers through the fundamental scientific principles of the field all the way to translational and practical clinical applications for treating and managing oncologic disease, but also provides a comprehensive understanding of the regulatory processes that support the safe and effective delivery of immunotherapy to patients with cancer.The expanded and updated second edition now spans 68 chapters, including 12 new chapters, covering major topics and innovations that have shaped the rapid development of immunotherapy and its ascension into the standard of care as first-line treatment for a growing number of disease settings. New to this edition are chapters with deeper insight into our understanding of cancer genomics and determinants of response, immunogenic cell death, cancer and stromal cell-intrinsic pathways of immune resistance, cancer immune exclusion, adoptive cell therapy, metabolomics, tumor mutation burden, immunotherapy in combination with radiation therapy, synthetic biology, and more. Complete with detailed illustrations, tables, and key points for targeted reference, Cancer Immunotherapy Principles and Practice, Second Edition is the most comprehensive and authoritative resource for scientists and clinicians looking to expand their knowledge base of this dynamic field.Key Features:Offers key insights and perspectives on cancer immunology and immunotherapy treatments from renowned experts in the fieldCovers the basic principles and science behind cancer immunotherapy and tumor immunologyIncludes treatment strategies for a vast array of available immunotherapy classes and agents, such as cytokine therapies, oncolytic viruses, cancer vaccines, CAR T therapies, and combination immunotherapiesProvides essential information on FDA-approved immunotherapies, including clinical management and outcome data related to response rates, risks, and toxicitiesDiscusses special considerations for immunotherapy in the context of specific disease settings, including skin cancers, genitourinary cancers, gastrointestinal cancers, hepatocellular carcinomas, gynecologic malignancies, breast cancers, lung cancers, head and neck cancers, brain tumors, sarcomas, pediatric cancers, and treatments combined with radiation therapyClarifies the complex regulatory aspects behind the development and approval of immunotherapy drugsPurchase includes access to the eBook for use on most mobile devices or computersPublisher: Springer Publishing Company Read more

Consumers increasingly are turning to complementary medicine, such as acupuncture, chiropractic, naturopathy, massage therapy, dietary supplements and herbs, energy healing, meditation and yoga, and mind-body therapies. This book addresses the growing interest in the legal, ethical, and regulatory aspects of integrating such care into conventional clinical settings.Integration of divergent philosophies, paradigms, and practices requires responsible investigation, informed judgment, and open-minded yet critical study and analysis of various systems of healing. Michael H. Cohen offers providers and policymakers vitally important information by addressing questions such as credentialing, malpractice, informed consent, and liability for referrals. He describes both practical strategies for minimizing liability, as well as the necessary future evolution of the legal and regulatory structure.Cohen also probes uncharted ethical and bioethical issues in complementary medicine and integrative health care. He further explores the connection between law, medicine, and spirituality and the role of this connection in human evolution. The book's range mirrors the integrative process itself, a process of grappling with, and meaningfully assimilating, disparate traditions and unfamiliar ways of thinking about the significance of health, body, and being.Beyond Complementary Medicine is required reading for anyone involved in health care, including executives, insurers, managed care organizations, attorneys, ethicists, and lawmakers; physicians integrating complementary and alternative therapies; complementary and alternative medicine practitioners; medical schools, law schools, and educational institutions offering programs in health care, public health, and complementary therapies; companies manufacturing herbs and dietary supplements; and most of all, patients and their families.Michael H. Cohen is President of the Institute for Integrative and Energy Medicine, a nonprofit organization in health care policy, ethics, and legal and regulatory affairs, and an attorney with an international practice in integrative health care. Read more

“How to Pass the FIFA Football Agent Exam” is a comprehensive, workbook-style guide designed for aspiring football agents looking to conquer the FIFA Football Agent exam. Created by sports law and agent expert Dr. Erkut Sogut and Jamie Khan, this resource combines decades of experience in sports law, agent training, and exam preparation. With insights drawn from helping over 1500 students pass the exam, the authors provide a detailed, step-by-step approach to mastering the legal and regulatory aspects of the FIFA agent certification.This guide offers a blend of theoretical knowledge, real-world case studies, and 15 mock exams and practical exercises that simulate the actual exam format, ensuring you are well-prepared for every aspect of the exam. Structured to build upon each chapter, the book covers everything you need to know, from legal frameworks to key concepts in football agency. Based on the most current FIFA study materials (as of March 2025), this workbook is an essential resource for anyone looking to succeed in the competitive field of football agency. Read more

The document titled "Missouri 2024 Electrical Code Chapter 1102" provides detailed information on electrical codes, regulations, and standards. Here is a summary of the key points covered in the first 15 pages out of 30:Title XI - Public Works and Building Regulations: This section introduces the chapters related to electrical codes, including definitions, adoption of the National Electrical Code, jurisdictional titles, and contracting with municipalities and fire protection districts for code enforcement services.Electrical Code Adoption: St. Louis County, Missouri, adopts the National Electrical Code (NEC) 2014 as published by the National Fire Protection Association as the electrical code for the regulation of electrical equipment within the county. The code includes regulations, provisions, penalties, conditions, and terms for electrical equipment regulation.Jurisdictional and Enforcement Details: The document specifies the jurisdictional title as "St. Louis County, Missouri," and defines the "Department of Electrical Inspection" as the "St. Louis County Department of Transportation and Public Works." It also outlines the process for contracting with municipalities and fire protection districts for code enforcement services.Administrative and General Provisions: The document details the administration of the electrical code, including the scope, intent, and general provisions for electrical systems within St. Louis County. It discusses the creation and powers of the Committee of Electrical Code Review and the Board of Electrical Examiners, including their duties, compensation, and appointment terms.Permit and Inspection Requirements: The document elaborates on the necessity of electrical permits, the application process, fees, and inspection requirements. It emphasizes the importance of maintaining electrical systems in compliance with the code and the responsibility of owners for safe maintenance.Code Compliance and Violations: The document outlines the procedures for compliance, including the issuance of permits, amendments, inspections, and the responsibilities of the Code Official. It also addresses violations, penalties, stop work orders, and the process for dealing with non-compliance.This summary only covers the first 15 pages of the document, which primarily focus on the administrative and regulatory aspects of electrical code enforcement in St. Louis County, Missouri. The document likely contains further detailed information on electrical standards, safety requirements, and specific electrical installation guidelines in the subsequent pages.For more detailed information or specific sections, you might consider accessing the document directly or asking for a summary of particular sections of interest. Read more

This book discusses the different regulatory pathways for Advanced Therapy Medicinal Products implemented by national agencies in North and South America, Europe and Asia and by international bodies in the effort of international harmonization.This book represents an update of the first edition, as it covers regulatory novelties and accumulated experience in the regions already addressed. In addition, this new edition offers a wider international perspective: new chapters are included covering Advanced Therapy Medicinal Products regulations in India, Malaysia, Spain and Thailand, the European Pharmacopoeia texts for gene therapy medicinal products as well as international harmonization programs. Each chapter, authored by experts from various regulatory bodies throughout the international community, walks the reader through the applications of nonclinical research to translational clinical research to licensure and therapeutic use of these innovative products. More specifically, each chapter offers insights into fundamental considerations that are essential for developers of Advanced Therapy Medicinal Products in the areas of product quality, pharmacology and toxicology, clinical trial design and HTA pathways, as well as pertinent ‘must-know’ guidelines and regulations. Regulatory Aspects of Gene Therapy and Cell Therapy Products: a Global Perspective is part of the American Society of Gene & Cell Therapy sub-series of the highly successful Advances in Experimental Medicine and Biology series. It is essential reading for graduate students, clinicians, and researchers interested in gene and cell therapy and the regulation of pharmaceuticals. Read more

The increasingly commercial nature of space activities and the intent of States to expand space travel have spawned renewed attempts of changing the foundations of space law, most of which originated in the twentieth century. Understanding the principles of international space law is essential for ensuring a sustainable future for all in outer space.International Space Law in the New Space Era addresses the international legal and regulatory aspects of outer space that govern developments in the field worldwide. It covers the five United Nations' space treaties along with soft law and other policies. With contributions from established experts in the domain of space law, the volume encompasses the entire gamut of international space law while simultaneously addressing inadequacies that have arisen in light of current developments such as space commercialization, space tourism, and space mining. Space law as an academic discipline is gaining prominence in law schools across the globe and this book is the result of a joint endeavour of two prominent Indian law universities (NUJS, Kolkata & MNLU, Mumbai), which have specialized centres in air and space laws. With its balanced mix of theory and practice, this book provides a timely and accessible resource to understanding international law not only for students and academics, but also for policymakers, practitioners, and those working in the space industry. Read more

Clinical Trials, Second Edition, offers those engaged in clinical trial design a valuable and practical guide. This book takes an integrated approach to incorporate biomedical science, laboratory data of human study, endpoint specification, legal and regulatory aspects and much more with the fundamentals of clinical trial design. It provides an overview of the design options along with the specific details of trial design and offers guidance on how to make appropriate choices. Full of numerous examples and now containing actual decisions from FDA reviewers to better inform trial design, the 2nd edition of Clinical Trials is a must-have resource for early and mid-career researchers and clinicians who design and conduct clinical trials.Contains new and fully revised material on key topics such as biostatistics, biomarkers, orphan drugs, biosimilars, drug regulations in Europe, drug safety, regulatory approval and moreExtensively covers the "study schema" and related features of study designIncorporates laboratory data from studies on human patients to provide a concrete tool for understanding the concepts in the design and conduct of clinical trialsIncludes decisions made by FDA reviewers when granting approval of a drug as real world learning examples for readers Read more

The value of the groceries purchases in the USA is over $500 billion annually, most of which is accounted for by packaged foods. Plastic packaging of foods is not only ubiquitous in developed economies, but increasingly commonplace in the developing world, where plastic packaging is instrumental in decreasing the proportion of the food supply lost to spoilage.This new handbook is a combination of new material and updated chapters, chosen by Dr. Sina Ebnesajjad, from recently published books on this subject. Plastic Films in Food Packaging offers a practical handbook for engineers, scientists and managers working in the food packaging industry, providing a tailor-made package of science and engineering fundamentals, best practice techniques and guidance on new and emerging technologies.By covering materials, design, packaging processes, machinery and waste management together in one book, the authors enable the reader to take a lifecycle approach to food packaging.The Handbook addresses questions related to film grades, types of packages for different types of foods, packaging technologies, machinery and waste management. Additionally the book provides a review of new and emerging technologies. Two chapters cover the development of barrier films for food packaging and the regulatory and safety aspects of food packaging.- Essential information and practical guidance for engineers and scientists working at all stages of the food packaging lifecycle: from design through manufacture to recycling- Includes key published material on plastic films in food packaging, updated specifically for this Handbook, and new material on the regulatory framework and safety aspects- Coverage of materials and applications together in one handbook enables engineers and scientists to make informed design and manufacturing decisions Read more