Selected as a Doody's Core Title for three years running!   A bestselling title in this highly regarded review series, Lippincott® Illustrated Reviews: Biochemistry is the go-to resource for both faculty and students for mastering the essentials of biochemistry. The fully revised 9th Edition helps students quickly review, assimilate, and integrate large amounts of critical and complex information, with unparalleled illustrations that bring concepts to life. An intuitive outline organization, chapter summaries, and review questions that link basic science to real-life clinical situations work together to clarify challenging information and strengthen retention and understanding, while an emphasis on clinical application, updated review tools, and accompanying digital resources prepare students for success on course and board exams and beyond. Every aspect of Lippincott® Illustrated Reviews: Biochemistry, 9th Edition, has been brought fully up to date, including: Student-friendly features such as chapter overviews, summaries, board-style questions and answers, Clinical Application boxes, case studies with questions and answers, online animations, and more. Vibrant illustrations and detailed tables that clarify complex biochemical concepts. Study questions and answers for each chapter that test students’ retention and strengthen their test-taking confidence. Integrative case studies with review questions familiarize students with commonly encountered clinical scenarios and alert them to potential widespread implications of presenting issues. Cross-references to other Lippincott® Illustrated Reviews titles that help students grasp how biochemical concepts relate to other basic sciences. Read more

The formation of disulfide bonds is probably the most influential modification of peptides and proteins. An elaborate set of cellular machinery exists to catalyze and guide this process. In recent years, significant developments have been made in both our understanding of the in vivo situation and the in vitro manipulation of disulfide bonds. This is the first monograph to provide a comprehensive overview of this exciting and rapidly developing area. It offers in-depth insights into the mechanisms of in vivo and in vitro oxidative folding of proteins as well as mono- and multiple-stranded peptides. Procedures applied for laboratory and industrial purposes are also discussed by top experts in the field. The book describes the enzymes involved in the correct oxidative folding of cysteine-containing proteins in prokaryotes and eukaryotes. It then goes on to discuss the mimicking of these enzymes for successful in vitro folding of proteins (including synthetic replicates) and to deal with important issues concerning cysteine-rich peptides. The ability of natural bioactive peptides to fold correctly, and in high yields, to form defined structural motifs using cysteine sequence patterns is still puzzling. With this in mind, synthetic procedures for establishing native cysteine frameworks are discussed using selected examples, such as the potential of selenocysteines. The biotechnological and pharmaceutical relevance of proteins, peptides, their variants and synthetic replicates is continuously increasing. Consequently, this book is invaluable for peptide and protein chemists involved in related research and production. Read more

Gain a thorough understanding of the principles of biochemistry as they relate to clinical medicineA Doody's Core Title for 2024 & 2023!The Thirty-Second Edition of Harper's Illustrated Biochemistry combines top-quality full-color illustrations with authoritative integrated coverage of biochemical disease and clinical information. Featuring numerous medically relevant examples, this respected text presents a clear, succinct review of the fundamentals that every student must understand in order to succeed in medical school.All 58 chapters help you understand the medical relevance of biochemistry.Full-color presentation with 600+ illustrationsChapters have been updated to reflect the latest informationCase studies emphasize the clinical relevance of biochemistryReview questions follow each of the 11 sectionsBoxed objectives define the goals of each chapterTables encapsulate important informationEach chapter contains a section on biomedical importance and a summary of the topics coveredApplauded by medical students for its current and engaging style, Harper’s Illustrated Biochemistry is an essential for USMLE review and the single best reference for learning the clinical relevance of any biochemistry topic. Read more

Immunoassays is the first practical volume designed to help any biologist develop an immunoassay of any common format for any suitable analyte. The basic principles are described and the choices of assay types and formats listed. Methods for raising and for characterizing antibodies, for preparing radioactive, enzymatic, fluorescent and other labels, are described. Solid-phase reagents, standards and immunogens are explained, with procedures for their preparation. But most components can be obtained commercially and comprehensive lists of suppliers are given. Approaches to combining the reagents and optimizing the required assay are described, including how to eliminate common interferences, and thorough validation procedures are given. Manual and computer methods for the calculation of concentrations are explained. Since only assays that are within control give valid results, a graded and comprehensive approach to internal and external quality assurance methods is detailed, including how to prepare control samples. Read more

Gain a full understanding of the principles of biochemistry as it relates to clinical medicineA Doody’s Core Title for 2022! The Thirty-First Edition of Harper’s Illustrated Biochemistry continues to emphasize the link between biochemistry and the understanding of disease states, disease pathology, and the practice of medicine. Featuring a full-color presentation and numerous medically relevant examples, Harper’s presents a clear, succinct review of the fundamentals of biochemistry that every student must understand in order to succeed in medical school. All 58 chapters help you understand the medical relevance of biochemistry:• Full-color presentation includes more than 600 illustrations• Case studies emphasize the clinical relevance of biochemistry • NEW CHAPTER on Biochemistry of Transition Metals addresses the importance and overall pervasiveness of transition metals• Review Questions follow each of the eleven sections• Boxed Objectives define the goals of each chapter• Tables encapsulate important information• Every chapter includes a section on the biomedical importance of a given topicNEW TO THIS EDITION:• Emphasis throughout on the integral relationship between biochemistry and disease, diagnostic pathology, and medical practice• Hundreds of references to disease states throughout• New chapter addressing the biochemical roles of transition metals• Many updated review questions• Frequent tables summarizing key links to disease states• New text on cryo-electron microscopy (cryo-EM)• Cover picture of the protein structure of the Zika virus, solved by cryo-EMApplauded by medical students and online reviewers for its currency and engaging style, Harper’s Illustrated Biochemistry is essential for USMLE® review and the single-best reference for learning the clinical relevance of any biochemistry topic. Read more

Before I say anything about this book, I offer for your consideration the fact that I am not a student of biochemistry; I am a physics graduate student. My desire to learn about biochemistry had nothing to do with receiving any sort of degree. Then consider the fact that this is the only Amazon.com review I have ever written. These facts alone should tell you that I must have found this book pretty remarkable. This text was required for all three of the biochemistry classes I took as an undergraduate student, and it never let me down. It contains a positively HUGE amount of information, which Nelson and Cox have somehow managed to digest and present for the layperson in a way that is both engaging and understandable. The writing style is superb, and the visual aids are numerous and of exceptionally high quality. How many times while cramming for the next day's test at 3:00 am have you caught yourself reading material that isn't even covered on the exam, just because it's interesting? I Read more

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Very Short Introductions: Brilliant, Sharp, Inspiring From the simplest bacteria to humans, all living things are composed of cells of one type or another, all of which have fundamentally the same chemistry. This chemistry must provide mechanisms that allow cells to interact with the external world, a means to power the cell, machinery to carry out varied processes within the cell, a structure within which everything runs, and also governance through a web of interlocking chemical reactions. Biochemistry is the study of those reactions, the molecules that are created, manipulated, and destroyed as a result of them, and the massive macromolecules (such as DNA, cytoskeletons, proteins and carbohydrates) that form the chemical machinery and structures on which these biochemical reactions take place. It didn't take long for an understanding of the chemistry of life to turn into a desire to manipulate it. Drugs and therapies all aim to modify biochemical processes for good or ill: Penicillin, derived from mould, stops bacteria making their cell walls. Aspirin, with its origins in willow bark, inhibits enzymes involved in inflammatory responses. A few nanograms of botulinum toxin (botox), can kill by preventing the release of neurotransmitters from the ends of nerves and so leads to paralysis and death, or give a wrinkle free forehead (if administered in very tiny quantities).This Very Short Introduction discusses the key concepts of biochemistry, as well as the historical figures in the field and the molecules they studied, before considering the current science and innovations in the field, and the interaction between biochemistry, biotechnology, and synthetic biology. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable. Read more

This revised and updated text presents the computational and mathematical procedures underlying data collection, image reconstruction, and image display in computerized tomography. New topics: the fast calculation of a ray sum for a digitized picture, the task-oriented comparison of reconstruction algorithm performance, blob basis functions and the linogram method for image reconstruction. Features: Describes how projection data are obtained and the resulting reconstructions are used; Presents a comparative evaluation of reconstruction methods; Investigates reconstruction algorithms; Explores basis functions, functions to be optimized, norms, generalized inverses, least squares solutions, maximum entropy solutions, and most likely estimates; Discusses SNARK09, a large programming system for image reconstruction; Concludes each chapter with helpful Notes and References sections. An excellent guide for practitioners, it can also serve as a textbook for an introductory graduate course. Read more

The basic mathematics of computerized tomography, the CT scan, are aptly presented for an audience of undergraduates in mathematics and engineering. Assuming no prior background in advanced mathematical analysis, topics such as the Fourier transform, sampling, and discrete approximation algorithms are introduced from scratch and are developed within the context of medical imaging. A chapter on magnetic resonance imaging focuses on manipulation of the Bloch equation, the system of differential equations that is the foundation of this important technology. Extending the ideas of the acclaimed first edition, new material has been adeed to render an even more accessible textbook for course usage. This edition includes new discussions of the Radon transform, the Dirac delta function and its role in X-ray imaging, Kacmarz’s method and least squares approximation, spectral filtering, and more. Copious examples and exercises, new computer-based exercises, and additional graphics have been added to further delineate concepts. The use of technology has been revamped throughout with the incorporation of the open source programming environment R to illustrate examples and composition of graphics. All R code is available as extra source material on SpringerLink.From the reviews of the first edition:“This book is valuable, for it addresses with care and rigor the relevance of a variety of mathematical topics to a real-world problem. …This book is well written. It serves its purpose of focusing a variety of mathematical topics onto a real-world application that is in its essence mathematics.” –The Journal of Nuclear Medicine, Vol. 51 (12), December, 2010“This new book by Timothy Feeman, truly intended to be a beginner’s guide, makes the subject accessible to undergraduates with a working knowledge of multivariable calculus and some experience with vectors and matrix methods. …author handles thematerial with clarity and grace…” –The Mathematical Association of America, February, 2010 Read more

The book examines recent developments in regenerative medicine and the use of musculoskeletal ultrasound. Musculoskeletal regeneration has become a prominent research topic, no doubt due to the sociological and economic pressures imposed by the current ageing population. The ever expanding role of regenerative medicine and the identification as well as characterization of stem cells have introduced a major paradigm shift in the field of musculoskeletal and sports medicine as well as orthopaedic surgery. Whereas in the past, diseased tissue was replaced with allograft material, current trends in research revolve around regenerating damaged tissue.Specifically, regenerative medicine stands in contrast to the standard treatment modalities which impair the body’s natural abilities to facilitate endogenous repair mechanisms such as anti-inflammatory drugs; or destructive modalities (e.g., radiotherapy, nerve ablation, injections of botulinum toxin) and surgical interventions thatpermanently alter the functioning of a joint, bone or spine. When compared to other allopathic options (including knee and hip arthroplasty with a 90-day mortality rate of 0.7%), regenerative medicine treatment modalities have a lower incidence of adverse events with a growing body of statistically significant medical literature illustrating both their safety and efficacy. Focusing on the major values of regenerative medicine, this book with its 21 chapters is expected to fill an important void in the current literature. It will take that extra step to guide you in your day to day clinical practice. Featuring contributions from a large international group of leaders in regenerative medicine and musculoskeletal ultrasonography, this book is an authoritative reference for rheumatologists, physiatrists, sonographers, radiologists, physiotherapists and orthopaedic specialists. Read more

Protein folding and aggregation is the process by which newly synthesized proteins fold into the specific three-dimensional structures defining their biologically active states. It has always been a major focus of research in biochemistry and has often been seen as the unsolved second part of the genetic code. In the last 10 years we have witnessed a quantum leap in the research in this exciting area. Computational methods have improved to the extent of making possible to simulate the complete folding process of small proteins and the early stages of protein aggregation. Experimental methods have evolved to permit resolving fast processes of folding reactions and visualizing single molecules during folding. The findings from these novel experiments and detailed computer simulations have confirmed the main predictions of analytical theory of protein folding. In summary, protein folding research has finally acquired the status of a truly quantitative science, paving the way for more exciting developments in the near future. This unique book covers all the modern approaches and the many advances experienced in the field during the last 10 years. There is also much emphasis on computational methods and studies of protein aggregation which have really flourished in the last decade. It includes chapters in the areas that have witnessed major developments and are written by top experts including:computer simulations of folding, fast folding, single molecule spectroscopy, protein design, aggregation studies (both computational and experimental). Readers will obtain a unique perspective of the problems faced in the biophysical study of protein conformational behaviour in aqueous solution and how these problems are being solved with a multidisciplinary approach that combines theory, experiment and computer simulations. Protein Folding, Misfolding and Aggregation Classical Themes and Novel Approaches is essential reading for graduate students actively involved in protein folding research, other scientists interested in the recent progress of the field and instructors revamping the protein folding section of their biochemistry and biophysics courses. Read more

Lehninger’s Principles of Biochemistry earned acclaim for its presentation and organization of complex concepts and connections, anchored in the principles of biochemistry.  This legacy continues in the eighth edition with a new framework that highlights the principles and supports student learning. Read more

Clinical Biochemistry is a best-selling textbook, with global sales of well over 80,000. It is used across the world, and has been translated into ten languages. Over six successive editions, it has provided students with just the right amount of information they need to understand and apply clinical biochemistry in a clinical context. It is aimed fairly and squarely at those who are new to the subject, and is suitable for undergraduates across a range of courses including medicine, nursing, biomedical science, pharmacy and life sciences. Junior doctors will also find it useful.The seventh edition retains the same practical and patient-centred approach that has made previous editions so popular. Despite its accessibility, there is no 'dumbing-down': all essential information is covered. The illustrations, which are a major part of its visual appeal, have been revisited and updated.This book is an ideal source for understanding the background to biochemical tests and how they should be interpreted. It will help you apply your learning in the clinical context. The same basic structure that has proved successful previously has been retained; sections on core biochemistry, endocrinology and specialised investigations follow an introductory section.Clinical notes and case histories on help you to apply learning to clinical practiceCovers the bulk of routine analyses and their relevance to the clinical settingAddresses real-world practicalities, such as how modern hospital laboratories work, and how test results should be interpretedEach topic presented on a richly illustrated two-page spread for easier understandingMCQs for each chapterAccompanying e-book now includes some animationsA new chapter on the pancreas, as well as two chapters that explain how some analyses are done - methods involving antibodies, and methods that separate and identify analytes Read more

Serious Science with an Approach Built for Today’s StudentsThis one-semester Principles of General, Organic, and Biological Chemistry textbook is written with the same student-focused, direct writing style that has been so successful in the Smith: Organic Chemistry and two-semester General, Organic, and Biological Chemistry texts. Janice Smith draws on her extensive teaching background to deliver a student-friendly format--with limited use of text paragraphs, through concisely written bulleted lists and highly detailed, well-labeled “teaching” illustrations--that provides need-to-know information in a succinct style for today’s students. Armed with an excellent macro-to-micro illustration program and many applications to biological, medical, consumer, and environmental topics, this book is a powerhouse of student learning. Don’t make your text decision without seeing Principles of General, Organic, and Biological Chemistry, second edition by Janice Gorzynski Smith! Read more

It's obvious why only men develop prostate cancer and why only women get ovarian cancer. But it is not obvious why women are more likely to recover language ability after a stroke than men or why women are more apt to develop autoimmune diseases such as lupus. Sex differences in health throughout the lifespan have been documented. Exploring the Biological Contributions to Human Health begins to snap the pieces of the puzzle into place so that this knowledge can be used to improve health for both sexes. From behavior and cognition to metabolism and response to chemicals and infectious organisms, this book explores the health impact of sex (being male or female, according to reproductive organs and chromosomes) and gender (one's sense of self as male or female in society). Exploring the Biological Contributions to Human Health discusses basic biochemical differences in the cells of males and females and health variability between the sexes from conception throughout life. The book identifies key research needs and opportunities and addresses barriers to research. Exploring the Biological Contributions to Human Health will be important to health policy makers, basic, applied, and clinical researchers, educators, providers, and journalists-while being very accessible to interested lay readers. Read more

“Pearls for Leaders in Academic Medicine” is a collection of concise bits of advice for medical school administrators on how to manage the challenges of playing a leadership role. The book covers topics ranging from how to negotiate the terms of a contract once you have accepted an administrative position, to broaching difficult subjects like termination, to managing budget crises. The authors have several years of experience as leaders in academic medicine and each “pearl” is the product of their practical expertise.The book is formatted in a way that anyone who has gone to medical school will appreciate. Providing short, to-the-point answers to specific questions without the hassle of having to sort through unnecessary information. The “pearls” format is ideal for the busy faculty member who does not have time to waste.Humorous and easily accessible, “Pearls for Leaders in Academic Medicine” is an invaluable resource for deans, department chairs, section chiefs and other senior level medical school administrators. However, it also provides insight for those considering a career as a leader in academic medicine, allowing them the benefit of advice from experienced leaders. Read more

Written by carefully selected global experts, practicing physicians, and educators in the various sub-disciplines of biochemistry, Medical Biochemistry, 6th Edition, offers a unique combination of research and clinical practice tailored to today's integrated courses. Covering clinically relevant topics in greater detail than other texts, this outstanding resource provides a strong overview of traditional areas in medical biochemistry along with state-of-the-art coverage of today’s latest developments. You’ll learn basic science concepts alongside clinical cases that describe patients likely to be encountered in clinical training, as well as how to use laboratory tests to diagnose and monitor the most important conditions. Thorough yet accessible, this clinically focused text is useful from medical school to clinical practice. Features a strong clinical orientation, emphasizing the relevance of biochemistry to the daily practice of medicineHighlights the latest developments in regulatory and molecular biology, signal transduction, age-related chronic disease, epigenetics, and bioinformatics and the “-omics,” as well as important global medical issues such as diabetes mellitus, obesity and malnutrition, cancer and atherosclerotic cardiovascular disease, and nutrition and exerciseEmphasizes clinical evaluation, maintenance of good health, and disease prevention, as well as translational medicine and the diagnosis and treatment of diseaseContains organ-focused chapters addressing the biochemistry of the bone, kidney, liver, lungs and muscle; and system-focused chapters on the biochemistry of the immune and endocrine systems, neurochemistry and neurotransmission, and cancerIncludes clear, colorful icons and illustrations that help you easily navigate the text and understand the materialProvides online features such as challenging “Active Learning” questions for independent study, relevant websites that reinforce or supplement chapter content, 150+ multiple-choice and USMLE-style questions, a quick-reference glossary, additional images and case studies, references to current literature, and moreEnhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices Read more

The following work on Biochemistry is offered to the public with a sincere desire to advance the cause of truth. The author has no desire to tear down anything good that may be found in any system of medicine. But this is an age of keen investigation of idol breaking and truth finding. He who is afraid to investigate for fear that some cherished belief will be swept away, is not a true scientist. Age cannot sanctify an error. It is with the kindest of feelings towards the science of Homoeopathy, and its many brave and noble defenders, that its underlying principle, similia similibus curantur has been questioned, and idem the same to the same, or the law of Supplying Deficiencies pushed to the front as the Natural Law of Cure. It is not claimed that all the matter in the book is original. It is absolutely necessary in preparing a text-book on Biochemistry, to use, in the main, the therapeutics and materia medica of Schuessler and the translator, Dr. M. Docetti Walker, of Dundee, Scotland. Some additions have been made, founded on experience. Hundreds of eminent physicians throughout the land have given time and experience that go to enrich the pages of the work. But the writer does claim originality in the biochemic pathology and the modus operandi of its therapeutics, and holds that his theories in regard to the manner and mode of operation, by which the inorganic cell-salts of human blood unite with organic matter to form certain material for carrying on life's processes, have never before been clearly set forth. Biochemistry is in its infancy. It is hoped the progressive physician will investigate, without prejudice, and thereby assist humanity to a true understanding of the cause and cure of disease. -The Author (originally published in 1894) Read more

Architects of Structural Biology is an amalgam of memoirs, biography, and intellectual history of the personalities and single-minded devotion of four scientists who are among the greatest in modern times. These three chemists and one physicist, all Nobel laureates, played a pivotal role in the creation of a new and pervasive branch of biology. This led in turn to major developments in medicine and to the treatment of diseases as a result of advances made in arguably one of the greatest centres of scientific research ever: the Laboratory of Molecular Biology in Cambridge, which they helped to establish. Their work and that of their predecessors at the Royal Institution in London reflects the broader cultural, scientific and educational strength of the UK from the early 19th century onwards. The book also illustrates the nurturing of academic life in the collegiate system, exemplified by the activities of, and cross-fertilization within, a small Cambridge college. Read more