Super Agers is a detailed guide to a revolution transforming human longevity. This is a breakthrough moment in the history of human health care. The person making that bold claim is one of the most respected medical researchers in the world, Eric Topol. Dr. Topol’s unprecedented, evidenced-based guide is about how you and your family and friends can benefit from new treatments coming available at a faster rate than ever. From his unique position as a leader overseeing millions in research funding, Dr. Topol also explains the fundamental reasons—from semaglutides to AI—that we can be confident these breakthroughs will continue. Ninety-five percent of Americans over sixty have at least one chronic disease and almost as many have two. That is the essential problem this revolution is solving. He explains the power of the new approaches to the worst chronic killers—diabetes/obesity, heart disease, cancer, and neurodegeneration—and how treatments can begin long before middle age, and even long after. In thirty years, we will have five times as many people at least one hundred years old and they will be healthier than ever because of the breakthroughs Dr. Topol describes. The amazing discoveries Topol brings into sharp focus are deeply inspiring about our human potential. We can now realistically see how we can make considerable headway for preventing age-related diseases and may one day be able to slow the body-wide aging process itself. Read more

The noted inventor and futurist’s successor to his landmark book The Singularity Is Near explores how technology will transform the human race in the decades to comeSince it was first published in 2005, Ray Kurzweil’s The Singularity Is Near and its vision of an exponential future have spawned a worldwide movement. Kurzweil's predictions about technological advancements have largely come true, with concepts like AI, intelligent machines, and biotechnology now widely familiar to the public.In this entirely new book Ray Kurzweil brings a fresh perspective to advances toward the Singularity—assessing his 1999 prediction that AI will reach human level intelligence by 2029 and examining the exponential growth of technology—that, in the near future, will expand human intelligence a millionfold and change human life forever. Among the topics he discusses are rebuilding the world, atom by atom with devices like nanobots; radical life extension beyond the current age limit of 120; reinventing intelligence by connecting our brains to the cloud; how exponential technologies are propelling innovation forward in all industries and improving all aspects of our well-being such as declining poverty and violence; and the growth of renewable energy and 3-D printing. He also considers the potential perils of biotechnology, nanotechnology, and artificial intelligence, including such topics of current controversy as how AI will impact employment and the safety of autonomous cars, and "After Life" technology, which aims to virtually revive deceased individuals through a combination of their data and DNA.The culmination of six decades of research on artificial intelligence, The Singularity Is Nearer is Ray Kurzweil’s crowning contribution to the story of this science and the revolution that is to come.* This audiobook edition includes a downloadable PDF with illustrations and graphs from the book.PLEASE NOTE: When you purchase this title, the accompanying PDF will be available in your Audible Library along with the audio. Read more

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We are in the midst of a healthspan revolution that will enable us to live vitally beyond 100 years old. Advanced diagnostics are now able to catch any disease at inception, while advanced therapies in clinical trials have the potential to reverse disease while also slowing, stopping, and potentially even reversing aging.Peter Diamandis, MD, designed Longevity Guidebook as an easy to use roadmap to help you understand the power of this healthspan revolution (driven by AI, CRISPR, gene therapy, and cellular medicine) and to inspire you to maintain your best health to intercept the transformative breakthroughs coming this decade.In this book, you will learn: That greater than 70 percent of your potential longevity is based on your lifestyle, not your genetics.How to implement proven lifestyle practices that will optimize your diet, sleep, exercise, and mindset, all enabling extended healthspan.About advances in diagnostic and therapeutic technologies that will enable you to find and reverse disease at the earliest time possible.How to "NOT die from something stupid," and about the breakthroughs that can save your life and the lives of those you love.LONGEVITY GUIDEBOOK is a practical reference guide that you can easily turn to as needed. It's time for you to shape your longevity mindset, and prepare to intercept the next wave of healthspan-extending breakthroughs expected during the decade ahead. Read more

For over half a century, DNA has dominated science and the popular imagination as the "secret of life." But over the last several decades, a quiet revolution has taken place. In a series of breathtaking discoveries, the biochemist Thomas R. Cech and a diverse cast of brilliant scientists have revealed that RNA-long overlooked as the passive servant of DNA-sits at the center of biology's greatest mysteries: How did life begin? What makes us human? Why do we get sick and grow old? In The Catalyst, Cech finally brings together years of research to demonstrate that RNA is the true key to understanding life on Earth, from its very origins to our future in the twenty-first century.A gripping journey of discovery, The Catalyst moves from the early experiments that first hinted at RNA's spectacular powers, to Cech's own paradigm-shifting finding that it can catalyze cellular reactions, to the cutting-edge biotechnologies poised to reshape our health. We learn how RNA may have jump-started life itself, and how, at the same time, it can cut our individual lives short through viral diseases and cancer. We see how RNA is implicated in the aging process and explore the darker depths of the supposed fountain of youth, telomerase. And we catch a thrilling glimpse into how RNA-powered therapies may enable us to improve and even extend life beyond nature's current limits. Read more

"The most important book on AI this year." --The Guardian"Mr. Russell's exciting book goes deep, while sparkling with dry witticisms." --The Wall Street Journal"The most important book I have read in quite some time" (Daniel Kahneman); "A must-read" (Max Tegmark); "The book we've all been waiting for" (Sam Harris)A leading artificial intelligence researcher lays out a new approach to AI that will enable us to coexist successfully with increasingly intelligent machinesIn the popular imagination, superhuman artificial intelligence is an approaching tidal wave that threatens not just jobs and human relationships, but civilization itself. Conflict between humans and machines is seen as inevitable and its outcome all too predictable.In this groundbreaking book, distinguished AI researcher Stuart Russell argues that this scenario can be avoided, but only if we rethink AI from the ground up. Russell begins by exploring the idea of intelligence in humans and in machines. He describes the near-term benefits we can expect, from intelligent personal assistants to vastly accelerated scientific research, and outlines the AI breakthroughs that still have to happen before we reach superhuman AI. He also spells out the ways humans are already finding to misuse AI, from lethal autonomous weapons to viral sabotage.If the predicted breakthroughs occur and superhuman AI emerges, we will have created entities far more powerful than ourselves. How can we ensure they never, ever, have power over us? Russell suggests that we can rebuild AI on a new foundation, according to which machines are designed to be inherently uncertain about the human preferences they are required to satisfy. Such machines would be humble, altruistic, and committed to pursue our objectives, not theirs. This new foundation would allow us to create machines that are provably deferential and provably beneficial. Read more

Beginning in the 1970s, several scientific breakthroughs promised to transform the creation of new medicines. As investors sought to capitalize on these Nobel Prize-winning discoveries, the biotech industry grew to thousands of small companies around the world. Each sought to emulate what the major pharmaceutical companies had been doing for a century or more, but without the advantages of scale, scope, experience, and massive resources.Biotech companies have met the challenge by creating nearly 40% more of the most important treatments for previously unmet medical needs. Moreover, they have done so with much lower overall costs.From Breakthrough to Blockbuster focuses on both the companies themselves and the broader biotech ecosystem that supports them. It paints a portrait of the crucial roles played by academic research, venture capital, contract research organizations, the capital markets, and pharmaceutical companies, demonstrating how a supportive environment enabled the entrepreneurial biotech industry to create novel medicines with unprecedented efficiency. In doing so, it also offers insights for any industry seeking to innovate in uncertain and ambiguous conditions. Read more

Meet the doctors, scientists, patients and campaigners tackling the world’s worst diseases ‘A must read.’ Siddhartha Mukherjee, bestselling author of The Emperor of All Maladies What does it take to create a new medicine? The trajectory from laboratory to your neighbourhood pharmacist rarely runs smooth. Drug hunting demands radical leaps of imagination, the expertise of many… and a hefty dollop of luck. Unsurprisingly, ‘eureka’ moments come few and far between – but, when they do, the effects can be life-changing. Charting the discovery of eight revolutionary drugs, Dr William Pao cuts to the innovative heart of the industry and celebrates the tireless work of the scientists, doctors, parents and patients fighting for better medical care. For each of these medicines, whether a potentially life-saving new treatment for cancer, or something as commonplace as paracetamol, there stands a cast of characters and a wealth of stories. Documenting these fascinating journeys, Breakthrough grants a privileged look at the stories behind the medicines that improve – and very often save – our lives. Foreword by Nobel Prize-Winner Harold Varmus *** ‘Utterly compelling.’ Dame Kate Bingham, author of The Long Shot ‘A celebration of medical innovation.’ Guardian ‘Captivating... An essential read.’ Art Levinson, former CEO of Genentech Read more

Walter Isaacson vuelve a fascinarnos, esta vez con la historia de Jennifer Doudna, Premio Nobel de Química 2020, y el avance científico más importante del último siglo.Hay una revolución en marcha, una tecnología prodigiosa que nos va a permitir curar enfermedades, derrotar virus y tener hijos más sanos. A su cabeza está la reciente premio Nobel Jennifer Doudna y sus colegas, protagonistas del nuevo libro de Walter Isaacson. Aunque su profesor de instituto le advirtió que las niñas no podían ser científicas, su búsqueda apasionada de los mecanismos ocultos de la vida y su voluntad por convertir descubrimientos en inventos llevaron a Jennifer Doudna a participar en el avance más importante en el ámbito de la biología desde el descubrimiento de la doble hélice del ADN. Con su equipo, transformó una curiosidad de la naturaleza en una herramienta que cambiará el rumbo del ser humano. El CRISPR, una técnica fácil de usar que permite modificar el ADN, lo que abre un mundo nuevo de milagros médicos pero también de cuestiones morales.El desarrollo del CRISPR (y la carrera por encontrar la vacuna del coronavirus) acelerarán nuestra transición a la siguiente gran revolución. Los últimos cincuenta años han sido una era digital basada en el microchip, el ordenador e internet. Ahora comienza la revolución de las ciencias de la vida. A los estudiantes de código digital se les unirán los que estudian el código genético.¿Deberíamos usar nuestras nuevas capacidades para hacernos menos vulnerables a los virus? ¿Y para prevenir la depresión? ¿Deberíamos aceptar que las familias que se lo puedan permitir mejoren la constitución física o la inteligencia de sus hijos? Tras dirigir el equipo que descubrió la tecnología CRISPR, Doudna ha liderado los debates en torno a estas cuestiones morales.Obtuvo, junto con su colaboradora Emmanuelle Charpentier, el Premio Nobel de Química en 2020. Su historia es una apasionante aventura que atraviesa las maravillas más profundas de la naturaleza, de los orígenes de la vida al futuro de nuestra especie.La crítica ha dicho...«El premio de este año tiene que ver con la idea de reescribir el código de la vida. Estas tijeras genéticas han llevado a la ciencia a una nueva era.» (Anuncio del Premio Nobel de Química 2020)«Un libro extraordinario que profundiza en una de las tecnologías biológicas más innovadoras de nuestro tiempo y las personas que la crearon. Brillante es una lectura absolutamente necesaria para nuestra era.» (Siddhartha Mukherjee)«Un libro vital sobre la última gran innovación científica, y otra biografía de primer nivel de Isaacson.» (Kirkus Weekly)Please note: This audiobook is in Spanish.NOTA: Cuando compre este título, el PDF que lo acompaña estará disponible en su Biblioteca Audible junto con el audio. Read more

Repackaged with a new afterword, this "valuable and entertaining" (New York Times Book Review) book explores how scientists are adapting nature's best ideas to solve tough 21st century problems.Biomimicry is rapidly transforming life on earth. Biomimics study nature's most successful ideas over the past 3.5 million years, and adapt them for human use. The results are revolutionizing how materials are invented and how we compute, heal ourselves, repair the environment, and feed the world. Janine Benyus takes readers into the lab and in the field with maverick thinkers as they: discover miracle drugs by watching what chimps eat when they're sick; learn how to create by watching spiders weave fibers; harness energy by examining how a leaf converts sunlight into fuel in trillionths of a second; and many more examples. Composed of stories of vision and invention, personalities and pipe dreams, Biomimicry is must reading for anyone interested in the shape of our future. Read more

Unlock the Power of Your CPHQ Preparation with Our Comprehensive Study Guide for 2025-2026!EXCLUSIVE LEARNING TOOLS INCLUDED:Audiobook Version: For on-the-go learning, making it easy to study anytime, anywhere.Digital Copy of the Guide: Always have your study material at hand, ready for review on any device.Extra eBook: Gain access to the "The Complete ABG Interpretation for Nurses" at no extra cost, enhancing your clinical knowledge.Over 700 Flashcards: Available in both PDF for printing and .APKG format for the Anki app, perfect for memorizing and reviewing key concepts effortlessly.Dive into the depth of the healthcare quality management profession with the latest edition of our CPHQ Exam Study Guide. Designed meticulously to support your journey toward CPHQ certification, this guide is not just a study aid—it's a beacon guiding you through the complexities of healthcare quality.Inside the guide:Integrate Core Concepts: Seamlessly blend theory and practical knowledge across essential quality management areas.Master Healthcare Quality Management: Understand the foundational principles of quality improvement, and utilize cutting-edge management tools and techniques.Elevate Patient Safety: Learn to identify, manage, and mitigate patient safety risks with proven strategies.Optimize Performance Measurement: Harness key performance indicators and enhance your skills in data collection and analysis.Navigate Healthcare Data and Analytics: Tackle modern challenges in data management and turn data into actionable insights.Lead with Confidence in Population Health and Case Management: Develop strategies for managing care and improving outcomes within diverse populations.Strategic Leadership and Governance: Step into the role of a leader with a solid grasp of governance and compliance in healthcare settings.Practice Tests & Answer Key: Validate your knowledge and readiness for the exam with comprehensive practice tests.Emerging Trends: Stay updated with the latest technological innovations and evolving standards in healthcare quality.Take the decisive step toward mastering the CPHQ exam and shaping your future in healthcare quality. This guide doesn't just prepare you to pass; it equips you to make a significant impact in the healthcare industry. Click 'BUY NOW' to begin your journey to becoming a Certified Professional in Healthcare Quality! Read more

BY THE WINNER OF THE 2020 NOBEL PRIZE IN CHEMISTRY  |  Finalist for the Los Angeles Times Book Prize   “A powerful mix of science and ethics . . . This book is required reading for every concerned citizen—the material it covers should be discussed in schools, colleges, and universities throughout the country.”— New York Review of Books    Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. That is, until 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the gene-editing tool CRISPR—a revolutionary new technology that she helped create—to make heritable changes in human embryos. The cheapest, simplest, most effective way of manipulating DNA ever known, CRISPR may well give us the cure to HIV, genetic diseases, and some cancers. Yet even the tiniest changes to DNA could have myriad, unforeseeable consequences, to say nothing of the ethical and societal repercussions of intentionally mutating embryos to create “better” humans. Writing with fellow researcher Sam Sternberg, Doudna—who has since won the Nobel Prize for her CRISPR research—shares the thrilling story of her discovery and describes the enormous responsibility that comes with the power to rewrite the code of life.“The future is in our hands as never before, and this book explains the stakes like no other.” — George Lucas“An invaluable account . . . We owe Doudna several times over.” — Guardian Read more

One of America's top doctors reveals how AI will empower physicians and revolutionize patient care Medicine has become inhuman, to disastrous effect. The doctor-patient relationship--the heart of medicine--is broken: doctors are too distracted and overwhelmed to truly connect with their patients, and medical errors and misdiagnoses abound. In Deep Medicine, leading physician Eric Topol reveals how artificial intelligence can help. AI has the potential to transform everything doctors do, from notetaking and medical scans to diagnosis and treatment, greatly cutting down the cost of medicine and reducing human mortality. By freeing physicians from the tasks that interfere with human connection, AI will create space for the real healing that takes place between a doctor who can listen and a patient who needs to be heard. Innovative, provocative, and hopeful, Deep Medicine shows us how the awesome power of AI can make medicine better, for all the humans involved. Illustrations note: 46 Halftones, black & white 11 Tables, black & white Read more

Join journalist Barry Werth as he pulls back the curtain on Vertex, a start-up pharmaceutical company, and witness firsthand the intense drama being played out in the pioneering and hugely profitable field of drug research.Founded by Joshua Boger, a dynamic Harvard- and Merck-trained scientific whiz kid, Vertex is dedicated to designing—atom by atom—both a new life-saving immunosuppressant drug, and a drug to combat the virus that causes AIDS. You will be hooked from start to finish, as you go from the labs, where obsessive, fiercely competitive scientists struggle for a breakthrough, to Wall Street, where the wheeling and dealing takes on a life of its own, as Boger courts investors and finally decides to take Vertex public. Here is a fascinating no-holds-barred account of the business of science, which includes an updated epilogue about the most recent developments in the quest for a drug to cure AIDS. Read more

The book cites the most recent scientific findings to provide a radically different approach to the formation and background of cancer, and also lays down the scientific foundations for a new, effective methodology of curing cancer.The author began his research in the early 1990s while investigating the role that deuterium (heavy hydrogen) plays in regulating biological and physiological processes. A number of leading universities and research institutes worldwide have joined the groundbreaking research.The book examines the most common conventional treatment methods in oncology and introduces the most effective combinations of treatments while providing detailed instructions in using deuterium depletion.Also discussed are deuterium depletion’s mechanism of action, the most important factors affecting effectiveness, and the main considerations when using the method. The method’s therapeutic potential is demonstrated through sixteen types of cancer, results from clinical trials, and specific case studies. One crucially important chapter describes how to use deuterium depletion to foster a healthy lifestyle. The last chapter contains recommendations for use, providing a helpful guide for health-conscious individuals or those struggling with the disease.The book strives to keep a balance between being easy to read or speaking in laymen's terms while providing a professional introduction of the research and clinical application to researchers and doctors. It discusses the treatment method based on deuterium depletion, which offers a tool of curing cancer and other chronic diseases, while also being more efficient and milder than any other oncotherapy up to now. Read more

An exploration of the once-ignored portion of our DNA and the role it plays in our bodies, from the author of The Epigenetics Revolution.For decades after the identification of the structure of DNA, scientists focused only on genes, the regions of the genome that contain codes to produce proteins. Other regions that make up 98 percent of the human genome were dismissed as "junk," sequences that serve no purpose. But researchers have recently discovered variations and modulations in this junk DNA that are involved with several intractable diseases. Our increasing knowledge of junk DNA has led to innovative research and treatment approaches that may finally ameliorate some of these conditions. Junk DNA can play vital and unanticipated roles in the control of gene expression, from fine-tuning individual genes to switching off entire chromosomes. These functions have forced scientists to revisit the very meaning of the word “gene” and have engendered a spirited scientific battle over whether or not this genomic “nonsense” is the source of human biological complexity. Drawing on her experience with leading scientific investigators in Europe and North America, Nessa Carey provides a clear and compelling introduction to junk DNA and its critical involvement in phenomena as diverse as genetic diseases, viral infections, sex determination in mammals, and evolution. We are only now unlocking the secrets of junk DNA, and Nessa Carey's book is an essential resource for navigating the history and controversies of this fast-growing, hotly disputed field.“Engaging, informative, and humorous.”—Sharon Y. R. Dent, University of Texas MD Anderson Cancer Center“A cutting-edge, exhaustive guide to the rapidly changing, ever-more mysterious genome.”—New Scientist Read more

Spend the day at work with Mass Spec Mommy and learn about the basics of mass spectrometry. Mass Spec Mommy helps children understand complex STEM concepts using colorful illustrations and kid-friendly story-telling. It's never too early to start training the next generation of mass spectrometrists! (STEM and Science Gifts for Kids) Read more

An insider's view on bringing extinct species back to lifeCould extinct species, like mammoths and passenger pigeons, be brought back to life? In How to Clone a Mammoth, Beth Shapiro, an evolutionary biologist and pioneer in ancient DNA research, addresses this intriguing question by walking readers through the astonishing and controversial process of de-extinction. From deciding which species should be restored to anticipating how revived populations might be overseen in the wild, Shapiro vividly explores the extraordinary cutting-edge science that is being used to resurrect the past. Considering de-extinction's practical benefits and ethical challenges, Shapiro argues that the overarching goal should be the revitalization and stabilization of contemporary ecosystems. Looking at the very real and compelling science behind an idea once seen as science fiction, How to Clone a Mammoth demonstrates how de-extinction will redefine conservation's future. Read more

The essential guide by one of America's leading doctors to how digital technology enables all of us to take charge of our health A trip to the doctor is almost a guarantee of misery. You'll make an appointment months in advance. You'll probably wait for several hours until you hear "the doctor will see you now"-but only for fifteen minutes! Then you'll wait even longer for lab tests, the results of which you'll likely never see, unless they indicate further (and more invasive) tests, most of which will probably prove unnecessary (much like physicals themselves). And your bill will be astronomical. In The Patient Will See You Now, Eric Topol, one of the nation's top physicians, shows why medicine does not have to be that way. Instead, you could use your smartphone to get rapid test results from one drop of blood, monitor your vital signs both day and night, and use an artificially intelligent algorithm to receive a diagnosis without having to see a doctor, all at a small fraction of the cost imposed by our modern healthcare system. The change is powered by what Topol calls medicine's "Gutenberg moment." Much as the printing press took learning out of the hands of a priestly class, the mobile internet is doing the same for medicine, giving us unprecedented control over our healthcare. With smartphones in hand, we are no longer beholden to an impersonal and paternalistic system in which "doctor knows best." Medicine has been digitized, Topol argues; now it will be democratized. Computers will replace physicians for many diagnostic tasks, citizen science will give rise to citizen medicine, and enormous data sets will give us new means to attack conditions that have long been incurable. Massive, open, online medicine, where diagnostics are done by Facebook-like comparisons of medical profiles, will enable real-time, real-world research on massive populations. There's no doubt the path forward will be complicated: the medical establishment will resist these changes, and digitized medicine inevitably raises serious issues surrounding privacy. Nevertheless, the result-better, cheaper, and more human health care-will be worth it. Provocative and engrossing, The Patient Will See You Now is essential reading for anyone who thinks they deserve better health care. That is, for all of us.

Science journalist Sally Adee breaks open the field of bioelectricity—the electric currents that run through our bodies and every living thing—its misunderstood history, and why new discoveries will lead to new ways around antibiotic resistance, cleared arteries, and new ways to combat cancer. You may be familiar with the idea of our body's biome: the bacterial fauna that populate our gut and can so profoundly affect our health. In We Are Electric we cross into new scientific understanding: discovering your body's electrome. Every cell in our bodies—bones, skin, nerves, muscle—has a voltage, like a tiny battery. It is the reason our brain can send signals to the rest of our body, how we develop in the womb, and why our body knows to heal itself from injury. When bioelectricity goes awry, illness, deformity, and cancer can result. But if we can control or correct this bioelectricity, the implications for our health are remarkable: an undo switch for cancer that could flip malignant cells back into healthy ones; the ability to regenerate cells, organs, even limbs; to slow aging and so much more. The next scientific frontier might be decrypting the bioelectric code, much the way we did the genetic code. Yet the field is still emerging from two centuries of skepticism and entanglement with medical quackery, all stemming from an 18th-century scientific war about the nature of electricity between Luigi Galvani (father of bioelectricity, famous for shocking frogs) and Alessandro Volta (inventor of the battery). In We Are Electric, award-winning science writer Sally Adee takes readers through the thrilling history of bioelectricity and into the future: from the Victorian medical charlatans claiming to use electricity to cure everything from paralysis to diarrhea, to the advances helped along by the giant axons of squids, and finally to the brain implants and electric drugs that await us—and the moral implications therein.  The bioelectric revolution starts here. Read more